Abstract 2460: The Impact of Increased Augmentation Index of Radial Pressure Waveform on Paroxysmal Atrial Fibrillation
The augmentation index, which is a marker of wave refection, has been reported to reflect vascular properties and left ventricular characteristics. We investigated the relationship between AI and paroxysmal atrial fibrillation (AF). A total of 244 outpatients (122 patients with paroxysmal AF and 122 age-, and gender-matched subjects without paroxysmal AF) were examined during sinus rhythm. The augmentation index was measured using applanation tonometry methods from radial artery and was calculated as the percentage of the second systolic peak relative to the first systolic peak from the radial arterial waveform. The augmentation index in patients with paroxysmal AF showed a significantly higher value than that in subjects without paroxysmal AF, after adjustment for age, gender, heart rate, and medications (87.0 ± 0.9% and 83.5 ± 0.9%, p=0.01). In all subjects, an increase in the augmentation index was significantly correlated with the left ventricular hypertrophy (r=0.264, p<0.001) and left atrial enlargement (r=0.268, p<0.001). To assess the effect of the augmentation index on paroxysmal AF, multiple logistic analysis was performed. The entire study population was categorized into quartiles based on the distribution of augmentation index. The interquartile cut off points were 78, 86, and 92%, respectively. The adjusted odds ratio for the prevalence of PAF was increased with quartiles (shown in Figure⇓). The present study demonstrated that an increase in the augmentation index of radial waveform was independently associated with paroxysmal AF.