Abstract 2456: Strong and Independent Association between Angiotensinogen Gene Polymorphisms and Hypertension in 10060 Patients with Stable Coronary Artery Disease
Angiotensinogen is an essential part in the blood-pressure regulation by the renin-angiotensin-system. To investigate whether the genetic polymorphisms in the angiotensinogen gene are related to hypertension. Hypertension was defined by study protocol as 160/95 mmHg or the use of antihypertensives. DNA was available in 10060 Caucasian patients with stable coronary artery disease. Eight polymorphisms in the AGT gene were genotyped based on functionality, location (promotor) or literature search. The Taqman allelic discrimination was used to determine all genotypes. Genotype information was available in 9689 subjects (97%). In multivariate logistic regression analysis we adjusted for age, gender, hypercholesterolemia, diabetes, prior MI, prior PCI, prior CABG, use of statins, beta-blockers, platelet-inhibitors and ACE-inhibitors. Mean age was 60 (Sd 9) years, and 85.7% were male. Minor allele frequencies ranged from 7– 46% (figure 1⇓). Results of the multivariate analysis are presented in figure 1 (reference category 1/1 normal alleles). Several minor alleles of polymorphisms in the AGT gene identified a 30 – 40% significant increased prevalence of hypertension. Genetic polymorphisms in the angiotensinogen gene are important to identify patients with hypertension. Sponsored by grants from the NHS-B219) and the Netherlands Organisation for Health Research and Development (ZonMW).