Abstract 2452: Presence of Early Cardiovascular Disease Markers within the Range of Prehypertension vs Normotension and Hypertension
Background: Cardiovascular abnormalities are frequently the cause, as well as the effect, of elevated blood pressure (BP). Early cardiovascular disease may be established before identifiable BP thresholds are crossed. Prehypertension has been considered as a precursor of hypertension. This study aimed to examine the difference of early markers for cardiovascular disease within the range of prehypertension divided in the BP range 120 –129/80 – 84 mmHg and BP range 130 –139/85– 89 mmHg vs normotension (<120/<80 mmHg) and hypertension (≥140/≥90 mmHg).
Methods: 1531 subjects (mean age 51.8 ± 11.3 years) free of overt cardiovascular disease attended a primary cardiovascular screening program and underwent measurement of large and small artery elasticity derived from radial pulse contour analysis, left ventricular mass index (LVMI) derived from ultrasonography, micro-albuminuria.
Results: Table 1⇓ summarizes results with P-values adjusted for age and gender. SBP: systolic blood pressure (mmHg); DBP: diastolic blood pressure (mmHg); LAE: large artery elasticity (ml/mmHgx10); SAE: small artery elasticity (ml/mmHgx100); LVMI: left ventricular mass index (g/m2): Micro-alb: micro-albuminuria (mg/mmol)
Conclusion: Early markers for cardiovascular disease are present before hypertension is observed. Therefore, hypertension might not be classified solely by discrete blood pressure thresholds.