Abstract 2313: Timing of Surgery in Infective Endocarditis and its Relationship to Mortality
Introduction The relationship between the timing of surgery and mortality in infective endocarditis (IE) has not been previously explored. We hypothesized that patients undergoing early surgery for complicated IE have similar outcomes to patients undergoing later surgery when corrected for pre-operative factors and survivor bias.
Methods We studied 62 patients who underwent surgery for left-sided IE. Survival at one year was compared between patients undergoing surgery within the first 14 days of admission (Group 1), between days 15 and 30 (Group 2), and after day 30 (Group 3). A landmark method was used to minimize the effect of survivor bias for later treatment, with day 30 set as the “baseline” for survival analyses. We also adjusted for known predictors of outcome including the Euroscore.
Results Patients undergoing earlier surgery were more likely to have severe heart failure, as well as higher predicted operative mortality rates.