Abstract 2226: Association between Framingham Cardiovascular Risk Score and Carotid Plaque Burden, Structure, and Composition: A Magnetic Resonance Imaging Study
Purpose We sought to identify the association between Framingham cardiovascular risk score (FCRS) and severity of carotid atherosclerotic disease.
Methods Seventy-five mainland Chinese subjects (72% male; age range: 37– 86) with carotid stenosis >50% by ultrasound underwent high-resolution carotid MRI. FCRS using age and gender adjustment were recorded for each individual. Plaque burden, as determined by normalized wall index (NWI = wall / total vessel area), and the prevalence of each component and the presence/absence of thin or disrupted fibrous cap were evaluated across the low, intermediate, and high 10 years Framingham CHD risk score strata.
Results The mean±SD arterial NWI for each FCRS category was 0.50±0.09 (low), 0.51±0.09 (intermediate), and 0.57±0.11 (high). From ANOVA, there were significant differences between FCRS categories (p=0.023). Significant differences in NWI were observed between low and high (p=0.007) and intermediate and high (p=0.047) FCRS groups. A significant difference was not observed in plaque burden between low and intermediate categories (p=0.750). No statistically significant difference in prevalence of plaque components and fibrous cap status was observed between FCRS categories (Table 1⇓).
Conclusions Greater plaque burden, as measured by NWI, is associated with higher risk FCRS categories. However, plaque features shown to be associated with increased risk in previous studies, such as intraplaque hemorrhage and thin/ruptured fibrous caps, were frequently found in subjects with low or intermediate 10 year FCRS. LRNC = lipid-rich necrotic core; CA = calcification; IPH = intraplaque hemorrhage; FC = fibrous cap