Abstract 2089: Randomized Controlled Trial of the Effects of Lifestyle Modification on Metabolic Coronary Heart Disease Risk Factors
Purpose: This study was to examine the effects of a six-month therapeutic lifestyle modification (TLM) program on metabolic coronary heart disease risk parameters in post menopausal Korean women with metabolic syndrome (Mets).
Methods: A randomized controlled design was used. Fifty four women with Mets were randomly assigned to receive a TLM program. The program was a six-month supervised weekly TLM session consisted of health monitoring, education, aerobic exercise, and a low calorie diet with low carbohydrate (≈1300Kcal/d). Those in the control group received a booklet about MetS and were instructed to maintain their usual diet and activities. Anthropometric measures, blood pressure, and serum cardio metabolic parameters were measured at before, during (month 3), completion (month 6), and after completion of the TLM program (month 12). Mixed-model repeated measures ANCOVA with control of age was used.
Results: Statistically significant treatment-by-assessment time interaction was observed for waist circumference (P = .010). Waist circumference decreased in the TLM group (d = − 9cm, 9.5%) over 12 months, compared with standard recommendation group (d = − 2cm). Systolic blood pressure (d = − 5mmHg, P = .017), HDL-cholesterol (d = + 4.6mg/dl, P = .041), and Triglyceride (d = + 3 mg/dl, P < .001) showed both treatment and time main effects. BMI showed a significant treatment effect (P < .001) and LDL-C had a time effect (P = .011). Fasting blood sugar (FBS) did not show treatment by time interaction or main effects (P > .05), however, treatment group returned to the normal range of FBS at month 12, while it did not in control group.
Conclusion: The results indicate that 6-month systematic TLM program have considerable beneficial effects on cardiometabolic risk factors in women with MetS.