Abstract 951: Femoral Plaques Confound the Association of Circulating Oxidized Low-density Lipoprotein with Carotid Atherosclerosis in a General Population Aged 35–55 Years (Asklepios Study).
Objective. Previously reported associations of oxidized low-density lipoprotein (OxLDL) with non-invasive measures of atherosclerosis were inconsistent. Moreover oxLDL was not an independent predictor of future cardiovascular endpoints in models adjusting for lipid markers (total and HDL-cholesterol). Therefore, in the Asklepios Study cohort of 2524 asymptomatic subjects aged 35–55 years, we evaluated the multiple-adjusted association between circulating OxLDL and subclinical atherosclerosis in the carotid and femoral arteries (ultrasound based definitions).
Methods and results. Participants (mean age 45 years, 51.5% females) underwent a clinical examination, ultrasound protocol for determination of intima-media thickness (IMT) and plaques (Mannheim criteria) in the left and right carotid and femoral arteries, blood analysis for OxLDL (mAb-4E6) and other risk markers. They all completed a lifestyle variables study questionnaire. OxLDL concentrations were highest in subjects with femoral plaques (n=658). In the group of subjects with carotid plaques (n=476), elevated OxLDL concentrations were related to concomitant femoral plaques detected in 54% of these subjects. Stepwise multiple regression for oxLDL comprizing classical covariates demonstrated that non-HDL-cholesterol (beta 0.41), HDL-cholesterol (beta −0.34), femoral artery plaque (beta 8.97), ln(triglycerides) (beta 4.89), and gender (beta 2.79) were significant (p < 0.05) determinants. Full models including all appropriate anthropometric, hemodynamic, biochemical, and lifestyle variables confirmed that femoral plaques are independently related to OxLDL. Similar analyses demonstrated that femoral IMT, carotid IMT, or carotid plaques were not independently associated with OxLDL.
Conclusion. Circulating OxLDL is independently associated with femoral plaque and not with carotid artery wall damage.