Abstract 908: Efficacy of Statin Treatment in Normocholesterolemic Patients with Coronary Artery Disease: Evaluation by Integrated Backscatter Intravascular Ultrasound: 6-month Prospective Study
Few data exist regarding the effect of statins, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, on tissue characterization on coronary plaques in normocholesterolemic patients with coronary artery disease (CAD). The aim of this study was to clarify statin-induced the change in tissue characteristics on coronary atherogenesis in normocholesterolemic patients using an integrated backscatter intravascular ultrasound (IB-IVUS). We compared plaque characteristics on IB-IVUS and serum lipid markers in normocholesterolemic patients with CAD (n = 26) at baseline and after 6-month statin treatment. Totally, 1,288 (each of 644 lesions at baseline and after 6-month) non-target coronary lesions with mild to moderate stenosis were measured. After 6-month treatment, significant decrease in percentage lipid pool area (from 49 ± 10 to 46 ± 10%, p < 0.05) and increase in percentage dense fibrous plaque area (from 50 ± 9% to 53 ± 9%, p < 0.05) were found. Compared to the baseline values, there were significant reduction in serum low-density lipoprotein (LDL) cholesterol (111 ± 34 vs. 97 ± 28 mg/dL, p < 0.005) and significant increase in serum high-density lipoprotein (HDL) cholesterol (46 ± 13 vs. 49 ± 12 mg/dL, p < 0.05). Percent changes in HDL-cholesterol levels were inversely correlated with changes in %lipid pool (r = 0.40, p < 0.05) and positively correlated with changes in %fibrous plaque (r = 0.44, p < 0.05). We demonstrated that six months statin treatment changed in tissue characteristics towards coronary plaque stabilization, accompanying the changes in HDL-cholesterol levels. These results provide further support for the beneficial effect of statin on tissue characteristics on coronary artery in CAD patients with not only hypercholesterolemia but also normocholesterolemia.