Abstract 862: Fundoscopy Examination May Be A Useful Clinical Tool For The Assessment Of Diffuse Vascular Damage
Objectives: In this study we investigated the relationships of retinal maladaptations with neurohumoral activation and arterial stiffening in the setting of essential arterial hypertension.
Methods: Our population consisted of 52-consecutive essential hypertensive non-diabetic subjects, stage I-II (21 men, mean age 62 years). All participants underwent ambulatory BP monitoring and complete echocardiographic study including evaluation of left atrial volume index (LAVI), left ventricular mass index (LVMI) and relative wall thickness (RWT). Arterial stiffness was evaluated on the basis of carotid-femoral pulse wave velocity (PWV), by means of a computerized method (Complior SP). Moreover, all patients underwent fundoscopy examination and according to Scheie grading system was classified into group A with those with normal examination or minimal arteriolar narrowing) and B obvious arteriolar narrowing and/or retinal hemorrhages and/or swollen optic nerve).
Results: Group A compared to group B did not differ with regard to age, sex, office and ambulatory BP parameters, as well as glucose levels and lipidemic profile. Regarding echocardiographic parameters no difference was also observed between the two groups with respect to LVMI, LAVI and RWT. Hypertensives in group B compared to those in group A exhibited higher values of PWV (9,86 vs. 8,91 m/sec, p=0,05).
Conclusions: Hypertensives with abnormal fundal examination, in the setting of similar cardiac adaptations, are characterized by increased aortic stiffening compared with those with normal fundoscopy. Fundoscopy examination provides a useful clinical tool for the assessment of diffuse vascular damage.