Abstract 857: Systolic Blood Pressure of 115 mmHg and Above is Associated with Worsening Cardiac Risk Profile in Normotensive Individuals
Aim: To explore whether a systolic blood pressure (SBP) cut-off of ≥115 mmHg is associated with worsening in the cardiac risk profile of healthy, normotensive individuals.
Background: Data from population based trials demonstrates an increase in cardiovascular events beginning with a SBP of 115mmHg. We sought to study the cardiac risk profile of healthy, normotensive individuals with SBP ≥115 mmHg.
Methods: A retrospective chart review was performed on all 391 consecutive live donors who were found healthy and eventually donated kidney between April 1997 and December 2005 at our institution. Pre-kidney donation profile collected included age, gender, race, body mass index [BMI], office blood pressure readings, fasting glucose (FBS), uric acid (UA), lipid profile and iothalamate GFR [iGFR]. We stratified patients into two groups based on systolic blood pressure cut-off value of ≥115mmHg. Continuous variables were compared between groups using independent samples t test, categorical variables were compared using chi square and Fisher’s exact tests utilizing a 2 sided p value < 0.05.
Results: The sample included 230 women (59%), 361 white patients (81%). Mean age was 41±9 years, SBP was 115.6 ± 15 mmHg, BMI 26.7 ± 4.24, UA 5.0 mg/dl ± 1, FBS of 87 ± 9 mg/dl and iGFR 106.47 ± 16.47 ml/min. Each of these risk factor variables was significantly elevated in the subgroup with SBP ≥115 mmHg when compared to those with lower SBP.
Conclusion: These data suggest that in otherwise healthy living donors a SBP of ≥115 mmHg is associated with a more adverse cardiac risk profile in comparison to those with a SBP less than 115 mmHg. Further studies are needed to see if instituting early interventions would improve cardiac profile and prevent cardiovascular events.