Abstract 817: Exercise Training Help to Maximise the Benefits for Patients Receiving Cardiac Resynchronisation Therapy
Cardiac Resynchronisation Therapy (CRT) is a recognised treatment for suitable patients with heart failure. The effect of exercise training in addition to CRT has not been investigated. 58 patients referred for CRT were recruited. Patients were randomised to either a control (n=31) or an exercise group (n=27). Patients were tested pre, and 3 and 6 months post CRT. At each visit the subjects performed maximal cardiopulmonary exercise testing. Peak lower limb skeletal muscle torque was measured using a Biodex isokinetic dynamometer. Between the 3 and 6 month test the exercise group underwent supervised exercise training 3 times a week, performing 20 min of walking and 10min of cycling at 80 % maximal heart rate. A repeated measures ANOVA with a Bonferroni post hoc test was used to look for statistical significance. At baseline there was no significant difference in any measure between the control and exercise group. At 3 months post both groups showed increases in NYHA class, Exercise Duration, Peak VO2, CPOPeak and CR. Skeletal muscle measure were unchanged. After exercise training there was a further increase in NYHA class, Exercise Duration, Peak VO2, CPOPeak, CR and peak lower limb torque during extension. In the control group no significant changes occurred in any measure except exercise duration during this time (see table⇓, results shown as mean (SE)). Exercise training after successful CRT leads to a further improvement in haemodynamic measures and skeletal muscle function. This allows for the maximum benefit of CRT to be realised with little additional cost.