Abstract 704: Left Ventricular Geometry Predicts Mortality in 26,216 Women with Preserved Systolic Function
Introduction: Numerous studies have indicated that left ventricular (LV) geometric patterns predict cardiovascular morbidity and mortality. Information regarding the prognostic impact of LV geometric patterns on mortality in a large cohort of female patients with preserved systolic function is limited.
Methods: The present study examines echocardiographic and clinical data in 26,216 female patients (mean age: 61.3 ± 16.0) with preserved ejection fraction to determine the impact of LV geometry, including normal structure, concentric remodeling, eccentric and concentric hypertrophy, on mortality during an average follow-up of 1.7±1.0 years.
Results: Abnormal LV geometry is very common in females with preserved systolic function, being present in 42% of this population, and was associated with significantly higher all-cause mortality (Table 1⇓). Although higher LV mass index, age and left atrial volume index and lower BMI were all independent predictors of higher mortality, higher relative wall thickness was by far the strongest independent predictor. (Table 2⇓)
Conclusion: These results indicate the prognostic impact of LV geometry, including concentric remodeling and frank hypertrophy, to predict mortality risk in women with preserved systolic functions.