Abstract 691: Regional Left Ventricular Myocardial Dysfunction in Pre-Diabetic and Diabetic Subjects: The Tagged MRI Study of the Multi Ethnic Study of Atherosclerosis (MESA)
Background: Left ventricular (LV) dysfunction is a major risk factor in patients with diabetes and has been reported in the absence of other known cardiac diseases. We evaluated systolic myocardial function by strain in patients with impaired fasting glucose or diabetes, but with no evidence of cardiovascular or renal disease.
Methods: MESA participants with normal LV mass, end-diastolic volume, ejection fraction, blood pressure, ECG, renal function and with no antihypertensive treatment, were selected and grouped according to fasting glucose test (normal, impaired or diabetes). Systolic circumferential strain was measured by MRI tagging at LV basal, mid and apical short-axes. Global myocardial function was measured as mean strain for the 3 short-axes. For multiple predefined comparisons we used ANOVA.
Results: Among the 260 selected subjects 27 had impaired fasting glucose and 33 had diabetes (Table 1⇓). At the midventricular level strain was lower in the 2 groups compared to the control group (16.5 ± 2.2 and 16.6 ± 2.0 vs. 17.9 ± 2.3, P<0.05, respectively). For global strain no differences were observed (Figure 1⇓).
Conclusion: Compared to healthy controls, not only patients with diabetes but also patients with impaired fasting glucose demonstrated reduced regional systolic strain. These results may have implications for risk stratification and treatment selection of pre-diabetic and diabetic patients with no evidence of cardiovascular or renal disease.
* These two authors contributed equally to this abstract.