Abstract 593: Hemodynamic Effect of a δ Opioid Receptor Agonist DADLE on Rats with Hemorrhagic Shock
Delta opioid receptor agonist can reduce the metabolism and energy demand of ischemic organs in ischemic/reperfusion injury. H-Tyr-D-Ala-Gly-Phe-D-Leu-OH (DADLE) is a delta opioid receptor agonist. In the present study, we investigated the hemodynamic effect of DADLE on rats with hemorrhagic shock. DADLE can improve the hemodynamics of rats with hemorrhagic shock. Thirty six healthy male SD rats were randomly divided into sham group, control group and DADLE group(1mg/kg group and 5mg/kg group). The control and DADLE animals were bled in 10 minutes by uninterrupted withdrawal from the arterial catheters to set up the model of hemorrhagic shock, then maintained MAP at about 40 mmHg for 60 minutes. All animals were observed for 3 hours after resuscitation with saline injection or DADLE injection and SAP, DAP, MAP, LVSP and ±dP/dtmax were recorded at 30, 60, 90, 120, 180 minutes following injection. After resuscitation, MAP, LVSP and ±dP/dtmax were unchanged in the control group, and remained downtrend. In contrast, significant increases(p<0.01) were found in all hemodynamic data following the administration of DADLE (1mg/kg or 5mg/kg), and the peak values were reached at 30 minutes. There was no significant difference between 1mg/kg and 5mg/kg DADLE groups. DADLE improves the hemodynamics during the course of hemorrhagic shock.