Abstract P119: End Diastolic Volume Remains Stable and Ejection Fraction is Improved During the First 3 Hours after Resuscitation When Sevoflurane is Administered During Cardio Pulmonary Resuscitation in a Rat Model of Cardiac Arrest
Introduction: Post resuscitation myocardial dysfunction is an important reason why patients die after initially successful resuscitation following cardiac arrest (CA). It is well known that volatile anesthetics protect the myocardium against ischemia reperfusion damage in regional ischemia in beating hearts.
Hypothesis: The aim of this study was to investigate if the application of Sevofluran starting with cardio pulmonary resuscitation (CPR), improves post resuscitation myocardial function in a rat model of cardiac arrest.
Methods: After institutional approval by the Governmental Animal Care Committee was obtained, male Wistar rats (350 – 400g) were randomized either to a group receiving Sevoflurane (2.5Vol%et; Sevo group) for five minutes starting at the beginning of CPR or to the control group. After 6 min of electrically induced VF, CPR was performed. Measurement of end diastolic volume (EDV), ejection fraction (EF), preload adjusted maximum power and stroke volume was performed using a pressure-volume-conductance catheter. The values were analyzed before CA (baseline), 1 h, 2 h and 3 h after ROSC. All data are given as mean ± SD (ANOVA; p<0.05).
Results: The rate of successfully resuscitated animals was the same in both groups (Sevo group 12/14, control group 12/15, p = n.s.). In the Sevo group EDV at baseline and during 3 h post ROSC was stable while EDV in the control group increased in the post ROSC phase. EF and preload adjusted maximum power at baseline was the same between both groups while there was a significant decrease in the post ROSC phase which was lower in the Sevo group than in the control group for both parameters (values see table⇓). There were no differences between the groups in the stroke volume values.
Conclusions: In this animal model of CA and resuscitation, Sevoflurane administered at the beginning of CPR was able to increase EF, preload adjusted maximum power and improved end diastolic volume as markers of myocardial function in the first three hours.