Abstract P96: The Hypothermia Registry; Cardiac Arrest and Long-Term Outcome
INTRODUCTION. Therapeutic hypothermia (TH) protects from neurological sequels and death after out-of-hospital cardiac arrest and it is recommended in the AHA Guidelines. The Hypothermia Registry is a database for patients treated with intensive care after cardiac arrest. We present the outcome in 941 consecutively TH treated patients from 35 hospitals in Europe and the US.
METHODS. Data on patient and cardiac arrest characteristics, hypothermia treatment, adverse events, clinical investigations and general intensive care was registered. Outcome was documented as neurological score at ICU and hospital discharge and at six months using the Cerebral Performance Category (CPC) scale: CPC 1–2 representing a good outcome and 3–5 a bad outcome.
RESULTS. The median age was 62 years, 73% were men and in 68% the initial rhythm was VT/VF. The time to initiation of TH was 90 minutes and the time to achieve core temperature less than 34°C was 240 minutes. Six month data were achieved in 931 (99%) of the patients. 53% were alive at follow up, of whom 92% had a good neurological outcome. Patients with shockable and non-shockable rhythms had a good outcome of 60% and 26% respectively. One hundred and one patients had a time to restoration of spontaneous circulation (ROSC) of more than 40 minutes with a six month good outcome rate of 27% (fig1⇓.)
CONCLUSION. More than 50% of an unselected cardiac arrest population admitted to intensive care for TH are alive at 6 months, most of them with a good neurological function. Patients with non-shockable rhythms have a better outcome than previously reported. We found an unexpectedly high survival rate in patients with time to ROSC > 40 minutes.