Abstract 12: Direct Mechanical Ventricular Actuation Significantly Augments Left Ventricular Function in Failing Rabbit Heart Model
Introduction: Direct Mechanical Ventricular Actuation (DMVA) is a unique non-blood contacting cardiac support device that augments ventricular function during both systole and diastole. The purpose of this study is to evaluate the role of DMVA in cardiac support for failing rabbit heart model (pediatric) using novel echocardiographic techniques.
Hypothesis: We hypothesize that DMVA significantly augments left ventricular function in a failing rabbit heart during both systole and diastole.
Methods: New Zealand white rabbits (n=5) were anesthetized, underwent sternotomy and instrumented for hemodynamic monitoring. A 10mHz ultrasound probe was positioned for trans-esophageal imaging. Heart failure (HF, cardiac output < 50% baseline) was induced with esmolol, then animals were supported using DMVA support. Phenylephrine was used to keep mean arterial pressure between 60 –70mm Hg. Echo clips during steady state conditions were assessed offline for ejection fraction, stroke volume and cardiac output using Simpson’s method of discs during baseline, HF and DMVA support.
Results: Conclusion: 2D-Echocardiography empowers us to investigate DMVA’s role in augmenting various hemodynamic parameters including ejection fraction, stroke volume and cardiac output. Our studies have shown sufficient evidence (increased stroke volume and end diastolic volume) in support of DMVA’s role in augmenting both systolic and diastolic function significantly, which is unique to it. DMVA has very promising prospect because of its uniqueness which no other direct cardiac compression device possesses.