Abstract 6273: Changes in Metabolic Parameters, Adiponectin, and High Sensitivity C-reactive Protein in South Asian Women Migrating to the United States: A 3-Year Follow-Up Study
Background: The incidence of cardiovascular disease in South Asian women is increasing, both in native and migrant populations. The reasons for this finding may be in part related to changes in lifestyle and alterations in cultural behavior.
Methods: We studied 301 healthy women (average age 28) recently migrated to the United States from the South Asian countries of India, Bangladesh, Pakistan, and Sri Lanka within 3 months of the time of arrival and at 3 years (31– 41 months) following their arrival. A questionnaire regarding activities pertaining to diet, physical activity, and socioeconomic status was performed. Measurements included changes in blood pressure (BP), total body weight, lipids, glucose, and determinations of high sensitivity CRP (hsCRP) and adiponectin from frozen serum specimen at these time points.
Results: In this diverse population, subjects reported an increase in food intake (including added salt and fat quantities) and no overall change in physical activity. Accordingly, there was a significant increase in total body weight after a 3 year period (119.7±14.4 to 127.9±15.3 pounds, p<0.005). There was a significant increase in serum LDL cholesterol (103.8±17.6 to 111.0±15.9 mg/dl, p=0.018), triglycerides (136.1±25.3 to 157.5±20.0 mg/dl, p=0.023), and glycosylated hemoglobin (4.9±0.7 to 5.3±0.6%, p=0.029). Moreover, the prevalence of diabetes mellitus (fasting glucose>125 mg/dl) increased from 3.3 to 9.7% in the 3-year follow-up period. There was an increase in serum hsCRP (1.80±0.19 to 2.05±0.18 mg/l, p=0.010) and a decrease in serum adiponectin (10.8±0.9 to 9.5±1.0 mg/l, p=0.022) in these subjects.
Conclusions: The population of South Asian women is at increased risk for cardiovascular disease and diabetes mellitus. Changes in lifestyle, including dietary intake and physical activity, affect parameters that may be crucial in the pathogenesis of these disease states.