Abstract 6263: Visceral Fat Area, but not Subcutaneous Fat Area, Is Associated with Lipid-Rich Coronary Plaque: Volumetric Integrated Backscatter Ultrasound Analysis
Visceral adipose tissue is major component of metabolic syndrome and associated with higher risk of cardiovascular events. We designed this study to evaluate association between coronary plaque characterization by integrated backscatter ultrasound (IB-IVUS) and visceral fat area (VFA). From Jan. 2006 to Dec. 2007, total of 76 patients who underwent coronary intervention following IB-IVUS and masurements of VFA/subcutaneous fat area (SFA) by CT were enrolled. Color coded maps of tissue characteristics of each 1mm slice in target lesions were constructed. Volume of each plaque components (calcification, fibrous and lipid core), percentage of lipid volume (% lipid; volume of lipid core/total plaque volume) and normalized lipid volume (volume of lipid core/lesion length) was calculated. We defined lipid-rich plaque as plaque with %lipid more than 42.6% which was 75th percentile of %lipid. VFA is larger in patient with hypertension than without (128cm2 vs 92cm2, p<0.05) and did not correlated with fasting glucose, HbA1c, HDL, TG and LDL level. In linear regression analysis, VFA significantly correlated with %lipid (r=0.25, p=0.03) and normalized lipid volume (r=0.32, p<0.01) in target lesion, but SFA did not (Figure⇓). VFA is significantly larger in patient with lipid-rich plaque than without (160±63 cm2 vs 105±50 cm2, p<0.01). In multiple logistic regression analysis, VFA is independent predictor for lipid-rich plaque after adjusting for age, gender and conventional risk factors (OR1.02/cm2 VFA, 95%CI 1.01–1.03, p<0.01). These results demonstrated potential role of visceral adipose tissue in developing lipid-rich coronary lesions.