Abstract 6208: The Association Of Metabolic Clustering And Physical Activity With Cardiovascular Mortality: The Hunt Study In Norway
The importance of physical-activity status in predicting premature cardiovascular death has mainly been reported in studies of asymptomatic populations. Whether physical activity compensates for the adverse effect of multiple cardiovascular risk factors is not well understood. The present study determined whether the positive association of a clustering of cardiovascular risk factors (CRF) with mortality could be weakened by exercise training in 49791 individuals who were free from known cardiovascular disease, and in 3751 individuals with CRF, at the beginning of follow-up between 1984 and 1986. We used the Cox proportional hazards model to estimate hazard ratios (HR) of cardiovascular death. People with CRF had a HR for cardiovascular mortality of 1.38 (95% CI, 1.28–1.48) compared to those without CRF. The effect of CRF was stronger among women than men. In people with CRF, there was a reduction in the risk of cardiovascular death with increased training. In the most physically active people with CRF, the reduction was 24% (HR, 0.76, 95% CI, 0.61–0.95) compared to the inactive with CRF. Compared to inactive healthy people, we observed a HR of 1.41 (95% CI, 1.16–1.70) in inactive people with CRF, whereas high physical activity in healthy people yielded a HR of 0.81 (95% CI, 0.72–0.92). HR associated high physical activity and CRF was 1.03 (95% CI, 0.82–1.29). We demonstrate that individuals with CRF are at greater risk of premature cardiovascular death compared to people without CRF, and that the risk of people with CRF who were most physical active appear to be comparable to that of inactive individuals without CRF.