Abstract 5136: Endurance Exercise Training Induces Similar Reductions in C-Reactive Protein in Elderly, Obese and Non-Obese Individuals
Aging and obesity are both associated with increased risk of cardiovascular disease, which occurs concomitantly with elevated inflammation. Weight loss decreases C-reactive protein (CRP), a marker of systemic low-grade inflammation. Yet, it is unclear if endurance training can elicit similar decreases in CRP independent of weight loss in an older, obese group.
Purpose: We determined the effects of endurance exercise training on CRP in an elderly, obese population using a randomized controlled trial design.
Methods: Elderly (70 yrs) non-obese (body mass index < 30 kg/m2) and obese (BMI > 30 kg/m2) men and women completed 10-mo of either flexibility exercises (Flex) or endurance exercise training 3 d/wk. Blood samples were batch analyzed for CRP both pre and post-intervention. CRP was log-transformed to account for a non-normal distribution. Aerobic capacity (VO2peak) was assessed using indirect calorimetry. Trunk fat was determined using dual energy x-ray absorptiometry.
Results: See table⇓ for data. As expected, the obese groups did have greater CRPlog, trunk fat, and lower VO2peak at baseline versus the non-obese (p<0.05). No interaction occurred with obesity status, however a time (Pre/Post) x treatment (Flex/Endurance) interaction was observed for CRPlog, VO2peak, and trunk fat (p<0.05). Endurance training reduced CRP and trunk fat and increased VO2peak (p<0.05), with no change in body weight.
Conclusions: This is one of the largest randomized control trials to date in elderly individuals using an exercise intervention and these data suggest that endurance training can attenuate systemic inflammation similarly in both elderly, non-obese and obese groups. This may be one of the first studies to demonstrate a change in CRP with exercise training without a change in weight, which may provide further evidence for the efficacy of exercise in an elderly population.