Abstract 5135: Influence Of Regular Physical Ativity On Regenerative Capacity Of Endothelial Progenitor Cells In School Children
Background: One of the markers associated the cardiovascular risk profile are circulating endothelial progenitor cells (EPCs). In patients (pts) with atherosclerosis the number of EPCs is strongly correlated with endothelial function. Recent studies demonstrated the beneficial effect of acute and chronic exercise on mobilization of circulating progenitor cells in adults. Aim of this study was to investigate the effect of daily school exercise lessons on the amount and function of EPC’s.
Methods: Eleven 6th-grade classes (131 boys, 151 girls) of three different high schools were randomized to an intervention group (IG) or a control group (CG). Students (Stds) of IG received one daily exercise lesson (45 min) with at least 15 minutes of endurance training. Stds of CG had their regular school sports consisting of 2 exercise lessons (each 45 min) per week. Three classes (31 boys, 20 girls) of a high school with special focus on competitive sports and physical education served as reference group (PE). In all children (159 boys and 163 girls, mean age 11.2 ± 0.4 years ) anthropometric data were recorded, laboratory analysis was assessed and a treadmill exercise test with spirometry was performed. The number of EPCs was assessed with FACS analysis and function of EPCs was determined via migration assay.
Results: After 1 year maximal oxygen consumption (VO2max) increased significantly in children of IG compared to children of CG (47.8 ± 1.7 ml/kg/min vs. 42.2 ± 1.2 ml/kg/min, p<0.001). However values of children of PE (56.2 ± 1.7 ml/kg/min, p<0.001 vs. IG und CG) were not reached. At baseline students of PE demonstrated a significantly higher amount of EPCs compared to students of IG and CG (403 ± 42 number/ml blood vs. 267 ± 38 number/ml blood in IG und KG (p<0.01)). After 1 year the amount of EPCs increased by 69% in Stds of IG, no change was observed in Stds of CG. Migratory capacity was significantly higher in Stds of PE compared to IG and CG.
Conclusion: The results of this trial demonstrate, that already in childhood, regular exercise and physical activity have a positive influence on exercise capacity and the amount of EPCs. Therefore, to prevent the negative consequences of physical inactivity and overweight/obesity early intervention to support exercise and movement is necessary.