Abstract 5076: Type 2 Diabetes but not the Coronary Angiographic State Is an Independent Determinant of Impaired Mobility in Angiographied Coronary Patients
Introduction: The determinants of impaired mobility in the high risk population of angiographied coronary patients are unknown; in particular a potential impact of type 2 diabetes and of the coronary artery state has not been investigated yet.
Hypothesis: We assessed the hypothesis that both type 2 diabetes and the coronary angiographic state are associated with impaired mobility.
Methods: We enrolled 747 consecutive patients undergoing coronary angiography for the evaluation of stable coronary artery disease (CAD). Coronary stenoses with lumen narrowing ≥50% were considered significant; mobility was assessed by the standardized timed-up-and-go (TUG) test.
Results: On average, our patients needed 9.6 ± 3.1 seconds to complete the TUG test, which showed impaired mobility (TUG time >10 sec) in 199 (26.6%) patients. The proportion of subjects with impaired mobility was significantly higher among patients with type 2 diabetes (T2DM) than among non-diabetic individuals (40.2% vs. 22.0%; p <0.001), whereas it did not differ significantly between patients with significant coronary stenoses and those without such lesions (p = 0.802). Multivariate adjustment in logistic regression analyses confirmed that T2DM (adjusted odds ratio (OR) = 2.05 [95% CI 1.35–3.11]; p = 0.001) but not the presence of significant coronary stenoses (adjusted OR = 0.81 [0.55–1.21]; p = 0.306) was independently associated with impaired mobility. Further independent determinants of impaired mobility were age (standardized adjusted OR = 3.27 [2.54 – 4.21]; p <0.001), female gender (adjusted OR 1.76 [1.16 –2.69]; p = 0.008), and body mass index (standardized adjusted OR = 1.49 [1.23–1.81]; p <0.001).
Conclusions: In conclusion, T2DM but not coronary atherosclerosis is an independent determinant of impaired mobility among angiographied coronary patients. Mobility enhancing exercise programs are needed for diabetic coronary patients.