Abstract 5018: Impact of Metabolic Syndrome on All-Cause and Cardiovascular Mortality According to Gender and Age
Aim: To evaluate the effect of metabolic syndrome (MetS) on all-cause and cardiovascular (CV) mortality according to gender and two groups of age.
Methods: The study population comprised subjects ≥40 years, with no history of CV disease (55,794 men and 28,936 women) examined for a standard health checkup at the IPC Center between January 1999 and December 2004. Mean follow-up was 4.7 years. During this period, 695 men and 234 women died (76 men and 28 women from CV disease). MetS was defined according to the NCEP2001 and IDF2005 definitions. Age was classified in two groups (<60 and ≥ 60 years). Mortality risk [Hazard Ratio (HR), 95%CI] was evaluated using Cox models including age, gender, tobacco consumption, physical activity, LDL cholesterol and socioeconomic status.
Results: Regardless of the definition, MetS was associated with an increased risk of all-cause mortality [HR=1.63 (1.38 –1.93) for NCEP, 1.25 (1.09 –1.45) for IDF] and CV mortality [HR=2.05 (1.28 –3.28) for NCEP, 1.77 (1.18 –2.64) for IDF] in the whole population. The increased mortality risk associated with MetS was similar in men and women. In contrast, the impact of MetS on mortality differed according to the age groups, with a significant interaction when the NCEP definition was used. For subjects <60 years, HR for all-cause mortality was 1.90 (1.52–2.37) with the NCEP definition, and 1.42 (1.17–1.72) with the IDF definition. The respective figures for CV mortality were 3.09 (1.66 –5.74) and 2.71 (1.54 – 4.75). For subjects ≥ 60, HR for all-cause mortality was 1.33 (1.02–1.74) with the NCEP definition and 1.11 (0.91–1.37) with the IDF definition. For CV mortality the respective figures were 1.41 (0.68 –2.93) with the NCEP and 1.30 (0.74 –2.30), with the IDFdefinition.
Conclusion: After a 4.7-year follow-up period and after taking into account major risk factors, the relation between MetS and mortality (all-cause and CV) was not influenced by gender. The risk of all-cause mortality associated with the presence of MetS was significantly higher among subjects <60 years than among those ≥60 years. A similar trend was observed for CV mortality.