Abstract 5004: Prehypertension and Mortality from Stroke and Coronary Heart Disease: 12 Years of Follow-up in Korean Men
Hypertension is a well-known risk factor for cardiovascular disease. However, there is little information on the impact of the recently-defined category of prehypertension (systolic blood pressure 120 to 139mmHg or diastolic blood pressure 80 to 89mmHg) on stroke and coronary heart disease (CHD). We assessed the impact of prehypertension on mortality from stroke and CHD in Korean men. We measured blood pressure and other cardiovascular risk factors in 108,461 Korean men, aged 35–59 in 1990 and 1992. Our primary outcomes were deaths from stroke and CHD in 12-year follow-up from 1993 to 2004. Independent relationships between baseline blood pressure levels and mortality from stroke and CHD were assessed using Cox’s proportional hazard models. Prehypertension was present at baseline in 47.4% of men. During 12 years of follow-up, 665 stroke deaths and 416 CHD deaths occurred. Compared to normotensive men, hazard ratios for men with prehypertension were 2.02 (95% confidence interval: 1.46, 2.78) for stroke and 1.87 (1.34, 2.62) for CHD after adjustment for age, body mass index, fasting serum glucose, total cholesterol, and cigarette smoking. In men with prehypertension, risk of both stroke and CHD increased with an increasing number of combined other risk factors. The impact of prehypertension on risk of stroke and CHD deaths could be different by combined other risk factors. Current findings indicate the need for identification of prehypertensive individuals, lowering their blood pressure, and control of combined risk factors.