Abstract 5003: Association of Blood Lactate with Hypertension: The Atherosclerosis Risk in Communities Carotid MRI Study
Background: The mechanism linking obesity with its downstream complications is poorly understood. Decreased aerobic capacity in obesity may play a central role in the development of hypertension. This hypothesis has not been examined in large population studies.
Methods: To test this hypothesis, we measured plasma lactate, an indicator of aerobic capacity, in 2066 older adults participating in the Atherosclerosis Risk in Communities (ARIC) Carotid MRI Study. We assessed the association of lactate with hypertension prevalence utilizing survey-weighted logistic regression.
Results: A graded association between plasma lactate and hypertension was observed. From the lowest to highest lactate quartile there was a three fold higher prevalence of hypertension (7.6%, 13.1%, 18.5% and 23.3%; p <0.001). Compared to subjects with lactate less than 5.9 mg/dl, the relative odds of hypertension rose with higher lactate quartile: 1.35 (95% CI: 0.96, 1.90), 1.73 (95% CI: 1.21, 2.47), and 2.21 (95% CI: 1.53, 3.22). The relative odds of hypertension with higher lactate quartile remained significant in models adjusting for age, sex, ethnicity, and BMI: 1.24 (95% CI: 0.87, 1.78), 1.64 (95% CI: 1.13, 2.37), and 1.72 (95% CI: 1.15, 2.57). The association was slightly attenuated with further adjustment for triglyceride, glucose and type 2 diabetes diagnosis, (relative odds of hypertension in 4th vs 1st lactate quartile, 1.58 95% CI: 1.06, 2.36).
Conclusions: High plasma lactate was independently associated with the odds of hypertension, suggesting that the decreased oxidative capacity may play an important role in hypertension prevalence.
This research has received full or partial funding support from the American Heart Association, AHA Mid-Atlantic Affiliate (Maryland, North Carolina, South Carolina, Virginia & Washington, DC).