Abstract 3281: Quercetin Glycoside Prevents the Development of Diet-Induced Obesity and Adipocyte Hypertrophy
Consumption of phenolic flavonoids in the diet was shown to be inversely correlated to lower morbidity and mortality from coronary heart disease. A previous study reported that the flavonoid quercetin, a food component with an excellent pharmacology safety profile, might act as a potent inhibitor of sugar absorption independent of its own transport, suggesting that flavonols are promising as new pharmacologic agents for the treatment of obesity. We investigate whether quercetin glycoside (QG) can prevent diet-induced obesity. Fifty male C57BL/6J mice were assigned to five groups: normal chow, high-fat and high-sucrose diet (HFS; 20% sucrose and 24% fat), HFS supplemented with 0.05% QG, 0.25% QG or 1.25% QG for 3 months. The final body weight of mice fed HFS was significantly greater than normal chow (39.83 ± 1.24 and 32.16 ± 0.55 g, respectively; P<0.01). Intake of QG suppressed the increase of body weight induced by HFS in a dose-dependent manner (38.36 ± 1.43, 37.1 ± 1.43 and 35.79 ± 1.45 g, in the 0.05% QG, 0.25% QG and 1.25% QG-supplemented groups, respectively). QG reduced the total weight of visceral adipose tissue (epididymal, mesenteric and perirenal white adipose tissue) in a dose-dependent manner (3.54±0.33, 3.26±0.26, 2.81±0.25 and 2.4±0.23 g, in HFS only, HFS with 0.05% QG, 0.25% QG and 1.25% QG-fed groups, respectively). The weight of mesenteric white adipose tissue was significantly decreased by intake of 0.25% QG as compared with HFS (0.55±0.04 and 0.77±0.07 g, P<0.05). Histological analysis demonstrated that the size of epididymal white adipocyte was significantly decreased in mice fed HFS containing 0.25% QG as compared with only HFS (4668.92±370.89 and 6574.57±439.76 μm2, P<0.05). QG tended to reduce the serum concentration of low-density lipoprotein cholesterol and triglyceride. QG intake decreased the serum leptin concentration in a dose-dependent manner. Neither serum concentration of glucose nor non-esterified fatty acid was changed by QG supplementation. Intake of QG could prevent the diet-induced obesity. QG might be useful to prevent diet-induce obesity.