Abstract 3275: Renoprotective Effect of Fish-Oil Supplement in Patients with Type II Diabetes
Introduction: Increased dietary fish-oil consumption is associated with a reduced risk of coronary heart events and has pronounced effects on dyslipidemia. However, the effects of fish-oil supplement on vascular function and metabolic prolife in patients (pts) with type II diabetes (DM) are unclear.
Method: In a double-blind controlled trial, we randomized 97 type II DM pts without prior cardiovascular diseases to fish-oil (4g/day) or olive-oil (with equivalent calorie as placebo) supplements for 12 weeks (wks). Brachial artery flow-mediated dilation (FMD), and metabolic parameters, including lipid prolife, hsCRP and renal functions were examined before and after the intervention.
Results: A total of 91 pts (60±9 years, 42 men) completed the study. There were no significant differences in age, prevalence of male, hypertension and smoking, and baseline FMD, lipid levels, HbA1c, hsCRP, creatinine clearance (CC) and glomerular filtration rate (GFR) between pts receiving fish-oil (n=45) or placebo (n=46) (P>0.05). Compared with placebo, 12 wks of fish-oil supplement significantly reduced serum triglyceride level (−0.54mmol/L, P>0.01), and increased CC (+3.7mL/min, P=0.02) and GFR (+4.3mL/min, P=0.04). Nevertheless, fish-oil supplement did not have any significant treatment effects on FMD, serum levels of hsCRP, low and high density lipoprotein, and HbA1c (all P>0.05).
Conclusions: This study demonstrated that 12 wks of fish-oil supplement in pts with type II DM had no significant beneficial effect on vascular endothelial function, but decreased serum triglyceride level and improved renal function without affecting the glycaemic control. Future long-term studies are needed to confirm the potential renoprotective effect of fish-oil supplement in pts with type II DM.