Abstract 3272: Effect of Non-Soy Legume Consumption on Cholesterol Levels: A Meta-Analysis of Randomized Controlled Trials
Studies evaluating the effect of legume consumption on cholesterol have focused primarily on soybeans, however non-soy legumes are more commonly consumed in the Western countries. We conducted a meta-analysis of randomized controlled trials to evaluate the effects of non-soy legume consumption on blood lipids, reported as either a primary or secondary endpoint, among adults. Studies were retrieved by searching MEDLINE (from January 1966 through October 2007) and EMBASE (from Jan 1980 to October 2007) using the medical subject headings: fabaceae not soybeans not isoflavones and diet or dietary fiber and cholesterol or hypercholesterolemia or triglycerides or cardiovascular diseases. Bibliographies of all retrieved articles were also searched. From 134 relevant reports, 13 randomized clinical trials were selected which compared a non-soy legume diet to control, had a minimum duration of 4 weeks, and reported blood lipid changes during intervention and control. Data on sample size, participant characteristics, study design, intervention methods, duration, and treatment results were independently abstracted by 2 investigators using a standardized protocol. Data from 13 trials representing 317 participants were examined using a random-effects model. Pooled mean net change in total cholesterol for those treated with a legume diet compared to control was 13.52 mg/dL (95% confidence interval [CI], 8.13 to 18.91); mean net change in low density lipoprotein (LDL) cholesterol was 10.80 mg/dL (95% CI, 4.69 to 16.92). These results indicate that a diet rich in non-soy legumes decreases total and LDL cholesterol.