Abstract 3267: Increased Aerobic Capacity is Associated with Decreased Fasting Insulin in Obese, African-American Female Adolescents
Introduction: The increasing prevalence of obesity in youth is linked with an increased CVD risk and the potential development of Type II diabetes. African-American females (AA) have been shown to be at greater risk for the development of Type II diabetes.
Purpose: This study was done to assess the relationship between changes in aerobic fitness and body composition on several components of the metabolic profile of obese, AA after participation in a clinical weight management program (CWMP).
Methods: Maximal aerobic fitness (VO2max), body composition (%fat), and fasting levels of insulin, glucose, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, attendance in structured exercise, and length of time to complete Phase I were measured before and following participation a CWMP. Phase I of the CWMP consisted of bi-weekly dietary counseling and participation in a structured exercise program. Data from 78 participants were used in the analyses.
Results: Following the intervention, significant, favorable changes occurred in VO2max, % fat, fasting insulin, glucose, and triglycerides. Step-wise multiple regression analyses suggested that a decrease in fasting insulin was significantly related to initial insulin and the increase in VO2max in AA when controlling for % fat. Additionally, in AA > 12 years (n = 57) initial insulin and the decrease in BMI were significantly related to the decrease in fasting insulin levels. Also, decreases in total cholesterol and LDL-cholesterol were significantly related to a decrease in % fat.
Conclusions: Improvements in aerobic fitness and body composition are related to a more favorable metabolic profile in obese, African-American female adolescents. Pediatric clinical weight management programming does result in significant short-term improvements in physical and metabolic functioning for these girls.