Abstract 3191: Exercise Training Increases Adiponectin Level In Patients With Stable Coronary Artery Disease
Purpose: Adiponectin, synthesized by adipose tissue reduces blood glucose, reverses insulin resistance and is thought to have protective effects on the endothelium. Decreased circulating adiponectin level is associated with progression of coronary artery disease in patients with stable coronary artery disease. Also regular physical exercise training is able to reduce cardiovascular events. A slowering of coronary artery disease progression was observed in patients that undergo regular exercise training. Aim of study was to evaluate the change in circulating adiponectin in patients with stable CAD underwent a regular physical exercise program compared to those underwent interventional therapy with stent implantation.
Method: In a subgroup of our PET-PILOT study adiponectin levels were measured from 96 patients with stable CAD at begin and after 24 months of therapy. After an initial coronary angiography with at least one significant coronary lesion patients were randomised either to a stent group or to an exercise training group. Patients of both groups received optimal medical treatment including beta-blocker, statins and ACE Inhibitors.
Results: 53 patients were randomized in the training group, 43 patients were treated in the stent group. After 2 years of follow up circulating adiponectin levels had increased by + 62.6% ± 26.6 vs. begin, p = 0.02 in the training group (change in concentration) whereas the adiponectin level of the stent group remain unchanged (+ 1.1% ± 12.8 vs. begin). No changes in weight were seen in both groups after 2 years of therapy.
Conclusion: In patients with stable coronary artery disease, long term exercise training on top of an optimized medical therapy was able to increase circulating adiponectin level independently to weight changes, thereby contributing to a better outcome in patients with CAD after the training intervention.