Abstract 3155: C-reactive Protein Levels Are an Independent Predictor Of Mortality in Patients Undergoing Percutaneous Coronary Intervention
Objective: To determine the association between Hs-CRP levels and mortality in patients undergoing PCI. Methods: 8834 consecutive patients undergoing (percutaneous coronary intervention) PCI between October 28, 2003 and January 1, 2007 were followed through June 30, 2007.
Findings: Hs-CRP levels were classified into four groups, <1.0, 1.0 –2.9, 3.0 –9.9, and greater than or equal to 10mg/L. Patients with higher Hs-CRP levels were more likely to be older, African-American, current and former smokers, have higher body mass index, LDL-cholesterol, triglycerides, diabetes mellitus, chronic kidney disease, a history of myocardial infarction, unstable disease and lower ejection fraction and HDL-cholesterol and were less likely to be on a statin. Mortality rates per 1000 person-years were 14.4, 17.5, 25.7, and 56.4 in patients with Hs-CRP levels of <1.0, 1.0 –2.9, 3.0 –9.9, and greater than or equal to 10mg/L respectively. After multivariable adjustment and compared to patients with a Hs-CRP <1.0 mg/L, the hazard ratios of mortality associated with Hs-CRP levels of <1.0, 1.0 –2.9, 3.0 –9.9, and greater than or equal to 10 were 1.16 (95% CI: 0.84 – 1.60), 1.51 (95% CI: 1.12 – 2.02), and 2.75 (95% CI: 2.06 – 3.66), respectively. A graded relationship between Hs-CRP and mortality was significant in patients with stable and unstable presentations (Table⇓).
Conclusions: In patients undergoing PCI, Hs-CRP levels provide incremental prognostic information for all-cause mortality in long-term follow up.