Abstract 3142: Do Known Genetic Factors Contribute to the Increased Risk of Cardiovascular Disease Amongst Indian Asians?
Background. We investigated whether the seven SNPs associated with CHD in recent genome-wide association studies, contribute to the two-fold higher risk of CHD amongst Indian Asians, compared to North Americans and European whites.
Methods. We examined the association of SNPs rs17465637, rs599839, rs6922269, rs1333049, rs501120, rs17228212, rs2943634 with prevalent CHD amongst 9,776 Indian Asian and 4,407 European white men and women, aged 35–75 years, participating in the London Life Sciences Prospective Population (LOLIPOP) study. Genotyping was performed by competitive allele-specific PCR (KASPar).
Results. CHD prevalence was higher amongst Indian Asians than Europeans (5.6% vs 3.8%, P<0.001). In comparison to Europeans, Indian Asians had higher prevalence of T2D and hypertension, but lower levels of cigarette smoking and cholesterol. SNPs rs599839, rs1333049, rs501120 and rs17228212 were associated with CHD amongst Indian Asians. Odds ratios (OR) for CHD were similar amongst Indian Asians and Europeans except for rs1333049, where OR was lower amongst Asians. For these four SNPs, risk allele frequencies were similar or lower amongst Indian Asians compared to Europeans (P<0.001). rs17465637, rs6922269 and rs2943634 were not associated with CHD. The OR for CHD amongst Indian Asians compared to European whites was 1.8 (95%CI 1.5 to 2.1, P=9.6×10−12) after adjustment for age and gender. With additional adjustment for CHD SNPs, the OR for CHD amongst Indian Asians compared to Europeans increased to 2.7 (95%CI 1.9 to 3.7, P=2.7×10−9).
Discussion. Known genetic variants show similar association with CHD, but have lower risk allele frequencies, amongst Indian Asians compared to Europeans. These genetic factors do not account for the two-fold increased risk of CHD amongst Indian Asians.