Abstract 3131: Primary Cardiac Malignant Tumors. Incidence, Trends and Survival.
Primary cardiac tumors are rare, and reported cardiac malignancies are less frequent than benign cardiac tumors. Related literature is primarily from autopsies reports, surgical series, or referral centers. Incidence reports ranged between 0.0017%, and 0.33%. Following the development of diagnostic methods, particularly noninvasive techniques, nonsurgical antemortem diagnosis has been increasingly possible. Data of primary cardiac malignant tumors in patients from 13 U.S. population-based cancer registries that participate in the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute, between 1973 and 2003 was extracted, using International Classification of Diseases for Oncology Third Edition codes. A total of 325 patients from the SEER registries were analyzed. Diagnosis was mostly conducted through biopsy (88%). One to 32 patients were diagnosed with primary cardiac malignancy each year, between the year of 1973 and 2003, with a total annual incidence of 0.36 per million. Blood vessel tumors and Lymphomas were the most common histology types. Males had higher incidence rates than females, 1.5:1. Incidence rate among Black populations was higher than incidence rate among other races. Since the year of 1973, annual incidence has increased 2–3 times, primarily in males, after the year of 1992 and for the histology type of Lymphomas. Primary cardiac lymphomas histology has become the most common histology type after 1992, representing 39% of primary cardiac malignant tumors by 2003. Annual incidence increased with increasing age, with a peak after age of 70 years. All-cause 5-year adjusted survival among patients with primary cardiac malignant tumors was 16.9%. It was slightly higher among females (21.9%) and white (17.5%), and significantly higher among primary cardiac Lymphomas (33.1%). Primary cardiac malignant tumors are rare, but incidence trend is increasing, mostly due to lymphoma histology type. This increase could either be due to actual numbers increase, or due to better cardiac imaging. Further studies should be focused on understanding the reason for this trend, early detection and management of primary cardiac malignant tumors.