Abstract 3115: Modification of the Effect of Glycemic Status on Aortic Distensibility by Age in the Multi-Ethnic Study of Atherosclerosis
Background: Elevated serum glucose from diabetes mellitus (DM) or impaired fasting glucose (IFG) shares many mechanisms with aging that decrease aortic distensibility (AD), such as glycation of the extra-cellular matrix. However, little data compares the simultaneous effects of elevated serum glucose and aging on AD. To study this, we examined the relationship between fasting glucose status, age, and AD in the Multi-Ethnic Study of Atherosclerosis (MESA): a multi-ethnic cohort of individuals aged 45– 84 years without clinical cardiovascular disease.
Methods: In MESA, participants with normal fasting glucose (NFG; n = 2270), IFG (n = 870), and DM (n = 412) underwent MRI assessment of proximal thoracic aortic distensibility. This sample was 46% male, 42% white, 30% AA, 11% Asian, and 17% Hispanic. The relationship between glucose status, age, and AD was analyzed with general linear models by adjusting for factors influential on AD including: race, body mass index, gender, serum LDL, HDL and triglyceride levels, mean arterial pressure, medication use, smoking history, and C-reactive protein. An interaction term was used to determine if age modified the effect of glucose status on AD.
Results: AD was lowest among those with DM. Comparing linear points at age 45, AD was significantly different between NFG and DM (p < 0.01), as well as between DM and IFG (p = 0.037). At age 45, AD approached difference in NFG vs. IFG (p = 0.052). The interaction term was also significant (p = 0.024).
Conclusion: Our data indicate that there are overall differences in AD between DM, IFG, and NFG. However, age modified the effect of glucose status such that differences between the groups diminished with advancing age.