Abstract 1270: Clinical Weight Status, Cardiac Disease and Mortality in Women of Diverse Racial/Ethnic Backgrounds
Obective: To examine how extreme obesity (≥40 kg/m2) influences health among women of diverse race/ethnicity.
Methods: We examined body size distribution and coronary heart disease (CHD) incidence rates over approximately 8 years in participants of the Women’s Health Initiative Observational Study or Randomized Control Trial cohorts who had a BMI ≥ 18.5 (n=143,805). Cox Proportional Hazard models assessed the association between weight status and mortality, CHD or congestive heart failure (CHF) risk in white, Hispanic or African American women.
Results: Extreme obesity prevalence varied from 0.9% (Asians) to 10.2% (African Americans) in the sample. Overall, CHD incidence per 10,000 person-years was much higher among extremely obese women (72.25; CI:65.02– 80.25) versus those with normal BMI (38.40; CI:36.63– 40.24). Point estimates showed a similar pattern in each racial/ethnic group. Modeling results for BMI categories are shown below; extreme obesity was linked with considerable risk for mortality, CHD and CHF in the 3 racial/ethnic groups. BMI hazard ratios were minimally impacted by further adjustment for physical activity. Modeling results were similar when examined by waist quintile, while only the top quintile of hip circumference was consistently associated with the outcomes.
Conclusions: Extreme obesity prevalence varied markedly by race/ethnicity. Among white, African American and Hispanic women, it was associated with considerable CHD, mortality, or CHF risk. Physical activity minimally lessened this risk.