Abstract 1198: The Relation Between Age and Serum Markers of Collagen Turnover in Healthy Elderly Individuals; The Cardiovascular Health Study
Background: Significant changes in the cardiac anatomy, morphology and function occur with aging. Increased collagen deposition in the myocardial matrix has been associated with prevalent heart failure (HF) in the elderly. The relation between age with serum level of procollagen type III aminoterminal peptide-PIIINP-, carboxyl-terminal propeptide type I -PIP-, reflecting collagen synthesis, and carboxyl-terminal telopeptide of collagen type I -CITP-marker of collagen type I degradation, is largely unknown in healthy free-living elderly individuals.
Aim: To determine the relation between age with serum biomarkers of fibrosis (SBF) in a large group of community-dwelling elderly individuals.
Methods: In 880 participants (ppts), mean age 77 ± 6 yrs, 52 % males, 79 % white, enrolled in the Cardiovascular Health Study, serum levels of PIIINP, PIP and CITP were measured; 179 had HF with normal LVEF (DHF), 131 had HF with LVEF < 55% (SHF), 287 controls (no HF), and 283 healthy ppts. Kruskal-Wallis test, one-way ANOVA, chi-square test and Spearman correlation were performed as appropriate.
Results: SFB values and the main demographic variables are displayed in the table⇓. The association between age with the 3 SBF for the entire study population were: PIP: r = 0.13 (p <0.0001), CITP: r = 0.13, p < 0.0001, PIIINP: r = 0.04, p = 0.20. For the individuals groups, the associations were: PIP with DHF (r = 0.25, p=0.001), CITP with DHF (r = 0.15, p =0.05), controls (r= 0.27, p < 0.0001) and healthy control groups (r = 0.19, p = 0.001). PIIINP was associated with age only in the control group (r = 0.12, p = 0.04). No association was found between age and SBF in the SHF group.