Abstract 5810: Pulse Pressure and Arterial Stiffness in Left Ventricular Geometry Types in Young Adults: From the Bogalusa Heart Study
OBJECTIVE: Arterial stiffness and increase in pulse pressure are independent risk factors for cardiovascular (CV) events and death. Differences in LV geometric models and in their CV risk may reflect the differential effects of pulse pressure and associated arterial stiffness on LV. In the present study, pulse pressure and arterial stiffness in LV geometry types were evaluated in a large community-based cohort of young adults.
METHODS: As part of the Bogalusa Heart Study, echocardiographic examinations of the heart were performed from 2000 to 2002 on 687 black and white adult subjects (age range 24 to 43 years, average 36; 42% men, 70% white). Arterial stiffness indices on the study cohort included aorta-femoral pulse wave velocity, carotid artery elastic modulus and arterial compliance by tonometry.
RESULTS: Pulse pressure in young adults with concentric LV hypertrophy (47 ± 11 mm Hg) was significantly higher than those with eccentric LV hypertrophy (40 ± 8 mm Hg, p <0.01) and normal geometry (37 ± 7 mm Hg, p <0.001). In addition, concentric LV hypertrophy was characterized by significantly higher pulse wave velocity, Peterson’s and Young’s elastic modulus, and lower large and small artery compliances compared with other geometry types. Multinomial logistic regression analysis revealed that pulse pressure (odds ratio (OR): 1.092, p = 0.007), presence of diabetes (OR: 9.6, p = 0.002), and body mass index (OR: 1.109, p = 0.022) were significant determinants of concentric type of LV hypertrophy compared with normal geometry. Pulse pressure and heart rate were the significant variables that persistantly associated with pulse wave velocity, Peterson’s and Young’s elastic modulus, large and small artery compliances (p <0.001 and p <0.05) in respective regression models.
CONCLUSION: These data suggest that concentric LV hypertrophy is characterized by significantly higher pulse pressure and arterial stiffness in young adults. The effects of pulse pressure and associated arterial stiffness may be a factor for the difference in LV geometric remodeling.