Abstract 6193: Renal Flow Reserve after Successful Percutaneous Renal Angioplasty Predicts Renal Functional Recovery
(Background) It has been reported that the renal flow reserve (RFR) can be estimated using intrarenal bolus injection of dopamine (50μg/kg). The purpose of this study was to assess the serial changes in RFR before and after percutaneous transluminal renal angioplasty (PTRA) in patients with atherosclerotic renal artery stenosis (ARAS) and to investigate its impact on renal functional recovery after PTRA.
(Methods) Eight patients with ARAS who underwent PTRA were enrolled and studied. Renal artery flow velocity at distal site of the stenosis was measured before PTRA using Doppler flow wire (FloWire, Volcano therapeutics, USA), and repeated after an intrarenal bolus injection of dopamine (50μg/kg). RFR was defined as renal artery averaged peak velocity (APV) at hyperemia divided by renal artery APV at baseline. Creatinine clearance (CCr) was measured before and after PTRA.
(Results) RFR were significantly increased after PTRA (1.79±0.58 vs. 2.08±0.57, p=0.03). Although RFR before PTRA did not correlate with CCr at baseline (r=0.02, p=0.86), RFR after PTRA correlated well with Ccr after PTRA (r=0.51, p=0.05).
(Conclusions) RFR increased significantly after successful PTRA. RFR after PTRA may predict the renal functional recovery.