Abstract 6132: Inflammation Activity of Vascular Plaque Is Increased in Patients with Acute Myocardial Infarction Assessed by Delayed FDG-PET Imaging
Background: To investigate whether acute coronary syndrome resulting from coronary plaque instability is associated with widespread vascular inflammation, we assessed carotid plaque inflammation activity using delayed whole body 18 FDG-PET imaging, better imaging protocol for active plaque detection, in patients with acute myocardial infarction (AMI) or chronic stable angina (SA).
Methods: In a total 44 (male 29, 64.1±12.7 yrs) patients who were newly diagnosed as acute myocardial infarction (21 patients, male 14, 59.8±13.2 yrs) or chronic stable angina (23 patients, male 15, 66.5±11.4 yrs), the 3-dimensional PET scanner together with a 16-slice Brilliance CT scanner using Gemini TF PET/CT (Philips Medical Systems) was performed within 1 week after disease onset. For the comparison of images acquired at 1 h and 2 h, the original axial slices were re-sliced to coronal images with 8 mm thickness and images acquired at 1 h and 2 h were displayed simultaneously using the same windowing and leveling. All ROI (region of interest) data were decay corrected to the injection time. The maximum standardized uptake values (SUVs) and standardized uptake ratios (SURs) were estimated in active plaques.
Results: Age and gender-adjusted SUV and SUR of FDG was significantly higher in the carotid plaques of AMI patients than in those of SA patients (p<0.001, Figure 1⇓ and 2⇓). There were no differences of risk factors between two groups.
Conclusions: The patients presenting with AMI have the increased inflammation activity in the carotid plaque. Our findings suggest that inflammation could contribute to widespread atherosclerotic plaque instability associated with ACS.