Abstract 6082: Sex Differences in Mortality after Acute Myocardial Infarction: Changes from 1994 to 2006
Introduction. In the past 10 years, several studies have shown that younger, but not older, women have a higher hospital mortality than age-matched men. We examined whether such mortality differences have declined in recent years.
Methods. We investigated temporal tends in the case fatality of MI according to sex and age (in 5 age groups) during a12-year period, 1994 to 2006. The study population included 916,380 MI patients from the National Registry of Myocardial Infarction (NRMI) who had a confirmed diagnosis of MI.
Results. Hospital mortality declined markedly between 1994 and 2006 in all patients, but more so in women than in men in virtually every age group. The mortality reduction in 2006 relative to 1994 was largest in women <55 years old (53%) and lowest in men <55 years old (33%). In patients <55 years, the absolute decline in mortality was 3 times larger in women than in men (2.7% vs 0.9%). The sex difference in mortality decline became progressively lower in older patients (p=0.002 for the interaction between sex, age and year). As a result, the excess mortality in younger women compared with men was less pronounced in 2004 – 06 than in 1994 –95 (Figure⇓). Changes in patient characteristics and treatments over time accounted in part for these mortality trends.
Conclusion. In recent years, women, particularly younger women, experienced larger improvements in hospital mortality after MI than men. As a result, the higher mortality of younger MI women compared with men has narrowed.