Abstract 6077: Advanced “Vascular Age” in Children with Dyslipidemia
Childhood obesity is a public health problem and its associated morbidities can result in advanced vascular age (VA). VA calculated using carotid intima-media thickness (CIMT) is advanced in obese children. A method for assessing burden of atherosclerosis may be determining VA by measuring CIMT. 70 high-risk children, aged 6 –19 years, underwent a carotid artery ultrasound scan using a high resolution probe. CIMT was calculated from multiple frames of the far wall of the commom carotid artery 2 cm proximal to the bifurcation using a semi-automated edge detection software. CIMT was used to gauge the child’s VA by comparing to CIMT percentile tables published for race and sex-matched adult population. Chronological age was 13.0±3.3 years. 62 (89%) were white, 34 (49%) were males. 41(59%) had a weight >95thile for age (64.0±23.4 kg). 40 (57%) had a body mass index (BMI) >95thile for age (25.6±6.0 kg/m2). 23 (33%) had systolic blood pressures (SBP) >95thile for sex, age and height (119.9±14.1 mmHg). Fasting lipid profile: total cholesterol 223.4±57.5 mg/dL, triglyceride 151.9±105.4 mg/dL, LDL cholesterol 149.8±59.0 mg/dL, HDL cholesterol 46.3±13.4 mg/dL, non-HDL cholesterol 177.1±54.6 mg/dL. Mean CIMT was 0.45±0.03 mm, maximum CIMT was 0.75 mm. By multiple regression analysis weight, BMI, & SBP were significant predictors of mean CIMT. Children with high fasting triglyceride levels were more likely to have an advanced vascular age. figure⇓ VA is advanced in children with obesity and risk factors and this association is strongest in children with high fasting triglyceride levels.