Abstract 6059: Novel Helical Stent Design Elicits Swirling Blood Flow Pattern And Inhibits Neointima Formation In Porcine Carotid Arteries
Background: Swirling blood flow patterns in the vasculature augments vessel wall shear stress, which in turn may, have a profound effect to suppress neointima formation. We tested whether helical-design peripheral stents would be effective in inhibiting neointima formation in porcine carotid arteries.
Methods: Helical stents (HS, 6.0×80mm) were implanted into one carotid artery, while straight metallic stents (SS, 6.0·80mm) were deployed in the contra-lateral artery in 10 farm pigs. Angiographic imaging and duplex ultrasound was performed immediately after implant to confirm presence of swirling flow and the time-averaged velocity (TAV) was measured proximal and distal to the stent. Angiographic mean lumen diameter within the stent (mLD) were also measured after implant and at one month follow-up. Stented carotid arteries were harvested for histologic analysis.
Results: A swirling pattern of blood flow was observed in all HS after implant and at one-month, but not in SS. mLD was similar between the groups after implant (HS: 5.0±0.4mm, SS: 5.0±0.4mm; P=0.903), while all animals showed higher mLD in HS at one-month (HS: 5.2±0.6mm, SS: 4.7±0.6mm; P=0.053). Full histomorphometric analysis was obtained from each stent.
Conclusion: A novel helical design promotes swirling blood flow and inhibits neointima formation in stented porcine carotid arteries, possibly due to the enhancement of vessel wall shear stress.