Abstract 6007: Arterial Responses at Proximal and Distal Edges of Everolimus-Eluting Stents: Insights from the Spirit III Randomized Controlled Trial
Edge stenosis has been raised as a potential limitation for drug-eluting stents. The aim of this IVUS study was to evaluate vessel response in adjacent reference segments (RS) after implantation of everolimus-eluting stents (EES). Data were obtained for lesions treated with a single EES from the SPIRIT III trial, a prospective, multicenter clinical trial to evaluate the efficacy of EES. IVUS analysis was performed at post-procedure and 8 months follow-up. Volume index (volume/length) was calculated for vessel (VA), lumen (LA), and Plaque (PA) in 5-mm vessel segments immediately proximal and distal to the stent. IVUS analysis was performed for the entire 5-mm RS and for each 1-mm sub-segment. Serial Volumetric IVUS data for RS were available in 71 lesions. There were significant increases in VA and LA in the distal RS and a trend toward a decrease in VA in the proximal RS (Table⇓). Millimeter-by-millimeter sub-segment analysis showed that these responses in VA were significant within the first 3mm distal and 2mm proximal RS (Graph). Despite the significant increase in PA within the first 1mm distal RS, LA was maintained due to the vessel expansion. Otherwise, significant LA increase was observed by 3mm in the distal RS (Graph). Significant lumen gain with vessel expansion was obtained at the distal reference after EES implantation.