Abstract 5950: Left Ventricular End Diastolic Pressure, Ejection Fraction, and BNP are Independent Predictors of Mortality
Little data exists on whether BNP, left ventricular end diastolic pressure (LVEDP), and left ventricular ejection fraction (EF) are independently predictive of cardiovascular events. We sought to determine the incremental predictive value of these variables for death, myocardial infarction (MI), and admissions for decompensated heart failure (HF) in patients referred for left heart catheterization. Patients referred for left heart catheterization at a single institution who had BNP and EF measurements within 24 hours of catheterization were eligible. Univariate and multivariate analyses were performed to evaluate the predictive ability of BNP, LVEDP, EF, and other confounding variables for death, MI, and heart failure admissions. 1054 patients were followed for a mean (±SD) of 3.1±2.2 years. BNP levels had a weak but statistically significant correlation with LVEDP and EF (r±0.18 and r=−0.39, p<0.001 for both). BNP had independent predictive value for death and heart failure admissions when included in a model with LVEDP, EF, and other confounding variables (Table⇓). LVEDP and EF had independent predictive ability for heart failure admissions but not for death. Neither BNP, LVEDP, nor EF was predictive of future MI.