Abstract 5784: Quantitative Analysis of Right Ventricular Function in Patients with Pulmonary Hypertension: Three-Dimensional Echocardiographic Study
Background: Assessment of right ventricular (RV) function by conventional two-dimensional echocardiography (2DE) remains challenging due to the complicated geometry. Although cardiac magnetic resonance imaging (MRI) is considered to be the gold standard for visualization of RV, real-time 3-dimensional echocardiography (RT3DE) is potentially applicable for RV volume measurements.
Methods: Twenty-eight patients with pulmonary hypertension (PH, pulmonary artery systolic pressure >50 mmHg) underwent both RT3DE and MRI. RT3DE imaging was performed from the apical window, and the 3D data sets were transferred to Q-Lab system (GI mode) for offline analysis. RT3DE measurements of the RV volume were indexed to body surface area included RV end-diastolic volume index (RVEDVI), end-systolic volume index (RVESVI), RV ejection fraction (RVEF), and Doppler study compared with those with MRI. Ten normal subjects underwent the same echocardiographic protocol for comparison.
Results: RVEDVI, RVESVI, and RVEF measured by RT3DE were well correlated with those by MRI (Figure⇓). Both RVEDVI and RVESVI were significantly enlarged in PH compared with normal subjects (RVEDVI; 126 ± 30 ml in PH vs. 74 ± 15 in normal, RVESVI; 91 ± 34 ml in PH vs. 26 ± 6.2 in normal, P<0.0001). RVEF was also significantly reduced in PH compared with normal (30 ± 13 % vs 64 ± 7.3 %, P<0.01). Furthermore, a significant negative correlation between RVSP and RVEF was observed (r=−0.61, p<0.0001).
Conclusions: RT3DE allowed accurate measurements of RV volumes when compared with MRI. The RV volume and function measured by RT3DE may be useful parameters for assessing the severity of RV dysfunction in patients with PH.