Abstract 530: Is Severe Hypertriglyceridemia (> 1000 mg/dl) a Risk Factor for Atherosclerosis ?
Severe Hypertriglyceridemia (SHTG) is believed to be a rare condition difficult to treat, but associated with a relatively low risk of morbidity, except for pancreatitis. In particular, SHTG is not believe to be a risk factor of atherosclerosis . Therefore, we performed a morbidity survey of SHTG patients being followed up for at least 2 years in the lipid clinics of the German Working Group. Evaluation of co-morbid conditions was based on patient chart review. The data of 893 SHTG cases (689 males (m), 204 females (f)) were compiled. As an admission criterion to the study SHTG patients had to have a documented TG > 1000 mg/dl prior to follow-up in the respective lipid clinics. Mean age was 50 ± 12 years, mean BMI was 28.7 ± 4.5. Upon admission to the lipid clinics mean TG was 2800 mg/dl (1000 – 16 000 mg/dl) and mean TC was 480 mg/dl (162–15920 mg/dl). Even after long term treatment in the lipid clinics mean TG and TC were still highly elevated (1190mg/dl and 322mg/dl, respectively). Regarding co-morbid conditions the following prevalence data were obtained: episodes of pancreatitis 24% (21% m,35%f), gallstones 21% (17% m, 32% f),hypertension 70%, diabetes 51 %, hyperuricemia 72 %. The prevalence of clinical manifestations of CVD was as follows : CHD by angiography 24% (27% m , 16 % f), MI 14 % (16% m, 5% f) , angina 21% (23% m, 17% f), PVD 15 % (14% m, 17% f), cerebrovascular disease 20 % (19% m, 24% f ). A total of 36 % of all SHTG patients (37% m, 33% f) showed at least one clinical manifestation of atherosclerotic cardiovascular disease. After excluding other risk factors 19% of remaining SHTG cases (20% m, 16 % f) still had clinical CVD. In conclusion, we were able to demonstrate a significant CVD burden in both male and female SHTG patients. SHTG itself seems to be an independent CVD risk factor.