Abstract 3793: Exercise Training Intervention After Coronary Angioplasty (The ETICA Trial): Ten-Year Follow-up
We have demonstrated in a randomized controlled trial that, at 3 year follow-up, exercise training significantly reduced cardiac event rate(RR 0.71,P=0.008 vs controls) as well as hospital readmission (RR 0.69,P<0.001 vs controls) in a group of 118 consecutive patients with coronary artery disease (CAD)(mean age 57 ± 10 years) who underwent PTCA(n=37) and stenting (n=82) in single(n=82) or multiple coronary arteries (n=37). We now present the results at 10-year follow-up. Both the intervention and the control groups were visited every 6 months and underwent a cardiopulmonary exercise stress testing every year. At 10 years, all patients underwent coronary angiography. Trained patients had a higher peak VO2 than untrained controls during the follow-up (mean difference 12.5 ± 5%,P<0.001) in relation to the greater amount of physical activity performed. Trained patients had a significant reduction in coronary artery progression (25% vs 62%,P<0.0001). Cardiac mortality (training=2; control=13, RR 0.76,P<0.001), new acute coronary syndrome (7 vs 31, RR 0.66, P<0.001), new PCI (6 vs 27, RR 0.64, P<0.0001) and new hospitalization rate (5% vs 19%, RR 0.74,P=0.005) were all lower in trained patients than controls. Multivariate analysis selected peak VO2 as the strongest independent predictor of events (P<0.001). In conclusion, trained patients maintains a higher peak VO2 than untrained controls during the follow-up. A more active life style was associated with improvements in all measures of outcome and a reduced CAD progression after 10 years from PCI.