Abstract 3788: Framingham and UKPDS Risk Scores Predict Extent and Severity of Coronary Disease as Determined by 64 Slice Coronary CT Angiography in Asymptomatic Patients With Type 2 Diabetes Mellitus
Background and aims: Framingham and UKPDS risk scores are clinically useful for long-term primary prediction of coronary heart disease (CHD) events. The relationship of these scores to extent of sub-clinical coronary atheroma is not known. We examined the correlation of 10 year CHD risk with extent of prevalent sub-clinical coronary atheroma using 64 slice coronary CT angiography (CTA) in asymptomatic pts with type 2 diabetes mellitus (DM) enrolled in an ongoing prospective outcomes study.
Methods: Contrast enhanced 64-slice CTA was performed in 172 consecutive diabetic pts with no known coronary disease (age 63.4 ± 5.6 yrs, 68% women, mean duration of DM 11.2 ± 8.0 yrs, 35% receiving insulin). Framingham and UKPDS 10 year risk scores were calculated from baseline pt characteristics.
Results: Distribution of risk to low, medium and high groups was similar for Framingham and UKPDS with <20% pts at low risk, nearly 50% at medium risk and one third at high risk. Multivessel coronary plaque was present in 90 (52.3%) pts. Prevalence of coronary plaque increased with level of both Framingham and UKPDS risk (Table⇓). Plaque prevalence correlated similarly with level of risk for both men and women. Variables not included in risk scores (Insulin treatment, ankle brachial ratio and serum CRP) were not predictors of multivessel plaque.
Conclusions: In asymptomatic pts with DM and no history of CAD undergoing 64 slice CTA 1. Multivessel plaque was common in pts at all levels of risk. 2. Prevalence of plaque increased with level of risk. 3. Both Framingham and UKPDS risk scores were predictors of the prevalence and extent of coronary plaque.