Abstract 3784: Hypertension Subtype and Risk of Cardiovascular Disease in Chinese Adults
We examined the relationship between hypertension subtype and cardiovascular disease (CVD) incidence and mortality in the Chinese adult population. We conducted a prospective cohort study in a nationally representative sample of 169,871 Chinese men and women aged 40 years and older. Data on blood pressure (BP) and other variables were obtained at a baseline examination in 1991 using standard protocols. Follow-up evaluation was conducted in 1999 –2000, with a response rate of 93.4%. Hypertension subtypes were defined as combined systolic and diastolic hypertension (SDH), isolated systolic hypertension (ISH), isolated diastolic hypertension (IDH), treated and controlled hypertension, and treated and uncontrolled hypertension. After excluding those participants with missing BP values, 169,577 adults were included in the analyses. Compared to normotensives, the relative risks (95% confidence interval) of CVD incidence and mortality were 2.73 (2.60 –2.86) and 2.53 (2.39 –2.68) for SDH, 1.78 (1.69 –1.87) and 1.68 (1.58 –1.78) for ISH, 1.59 (1.43–1.76) and 1.45 (1.27–1.65) for IDH, 2.01 (1.64 –2.48) and 1.61 (1.28 –2.03) for treated and controlled hypertension, and 3.37 (3.07–3.69) and 2.88 (2.60 –3.19) for treated and uncontrolled hypertension, respectively, after adjustment for baseline age, sex, education, cigarette smoking, alcohol consumption, physical inactivity, body-mass index, geographic region, urbanization and time-dependent history of diabetes. Our results indicate that all hypertension subtypes are associated with a significantly increased risk of CVD in Chinese adults. Primary prevention of hypertension should be a public health priority in the Chinese population.